Underutilization of Tissue Plasminogen Activator in Acute Ischemic Stroke Christopher M. Loar M.D. Tissue Plasminogen Activator (T-PA) Expert Witness Introduction Tissue Plasminogen Activator (T-PA, brand name Alteplase) is a medication that is given intravenously to dissolve blood clots. It is the only scientifically proven, effective treatment for acute ischemic stroke (1). Its use has been… read more